Notify sufferers of the potential risk of lifestyle-threatening respiratory despair, such as facts that the danger is greatest when starting up acetaminophen and codeine phosphate tablets or when the dosage is increased, and that it may possibly take place even at advisable dosages.
Mechanism of Motion Codeine is definitely an opioid agonist rather selective to the mu-opioid receptor, but having a A lot weaker affinity than morphine.
The concomitant utilization of acetaminophen and codeine phosphate tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may well result in a rise in codeine plasma concentrations along with a minimize in Lively metabolite morphine plasma concentration which could bring about an analgesic efficacy reduction or indicators of opioid withdrawal.
In scientific studies performed via the Countrywide Toxicology Application, fertility assessments with acetaminophen are concluded in Swiss CD-one mice by using a ongoing breeding review. There have been no effects on fertility parameters in mice consuming around 1.7 situations the MHDD of acetaminophen, based on a system area place comparison. Whilst there was no impact on sperm motility or sperm density from the epididymis, there was a big rise in The proportion of abnormal sperm in mice consuming 1.
Hepatotoxicity Acetaminophen has actually been affiliated with circumstances of acute liver failure, sometimes resulting in liver transplant and Demise.
Remember that this medication continues to be prescribed due to the fact your medical professional has judged the benefit for you is bigger than the potential risk of Negative effects. A lot of people applying this medication do not have severe Negative effects.
Get rid of expired, unwanted, or unused acetaminophen and codeine phosphate tablets by having your drug to a certified DEA-registered collector or drug get-back method. If one particular just isn't available, you may get rid of acetaminophen and codeine phosphate tablets by mixing the item with Dust, cat litter, or espresso grounds; putting the combination inside of a sealed plastic bag, and throwing the bag as part of your trash. Pay a visit to for additional info on disposal of unused medicines.
Codeine and its Lively metabolite, morphine, are existing in human milk. You can find released research and cases that have reported excessive sedation, respiratory depression, and death in infants exposed to codeine by way of breast milk. Females who will be extremely-fast metabolizers of codeine accomplish greater than envisioned serum amounts of morphine, probably leading to better levels of morphine read more in breast milk that may be dangerous of their breastfed infants.
Extensive-term scientific studies To guage the carcinogenic probable of The mix of codeine and acetaminophen have not been executed.
Retailer acetaminophen and codeine phosphate tablets securely, away from sight and access of kids, As well as in a site not obtainable by Other people, including guests to the home.
Be sure you know the way to choose this medication and click here what other medicine you ought to avoid having with it. See click here also Drug Interactions segment. Get health care aid right away if any read more of these really serious Uncomfortable side effects arise: slow/shallow respiratory, uncommon check here lightheadedness, intense drowsiness/dizziness, trouble waking up.
All individuals treated with opioids involve thorough and Repeated reevaluation for signs of misuse, abuse, and addiction, because usage of opioid analgesic products carries the potential risk of dependancy even underneath proper professional medical use.
The prescriber have to figure out the volume of tablets per dose, and the utmost number of tablets per 24 hours, primarily based upon the above mentioned dosage steering. This data must be conveyed while in the prescription.
Examine the Medication Manual supplied by your pharmacist Before you begin using acetaminophen/codeine and every time you will get a refill. When you've got any concerns, ask your medical professional or pharmacist.